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It is not likely that naltrexone will cause liver damage when taken in recommended doses. Using the same amount you used before could lead to overdose or death. Tell your doctor if you start using drugs or alcohol again. Its overall benefit has been described as "modest". Due to this issue, the usefulness of oral naltrexone in opioid use disorders is limited by the low retention in treatment. The challenge involves giving a test dose of naloxone and monitoring for opioid withdrawal. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Subsequent studies have suggested limited toxicity in other patient populations. This may help you drink less or stop drinking completely. When naltrexone is taken at home, it is usually taken once a day with or without food. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. The person takes the medication about an hour (and only then) before drinking to avoid side effects that arise from chronic use. Follow your doctor's instructions very closely. When naltrexone is taken in a clinic or treatment center, it may be taken once a day, once every other day, once every third day, or once every day except Sunday. It has benefits over methadone and buprenorphine in that it is not a restricted medication. Naltrexone will help you avoid using drugs and alcohol, but it will not prevent or relieve the withdrawal symptoms that may occur when you stop using these substances. Continue to take naltrexone even if you feel well. Naltrexone will not cause you to "sober up" and will not decrease the effects of alcohol you recently consumed. Your doctor may give you another medication (naloxone challenge test) to check for opiate use. The opioid antagonist blocks the positive-reinforcement effects of alcohol and allows the person to stop or reduce drinking.

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