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Naltrexone, sold under the brand names ReVia and Vivitrol among others, is a medication primarily used to manage alcohol or opioid dependence. After taking naltrexone, your body will be more sensitive to opioids. When naltrexone is taken in a clinic or treatment center, it may be taken once a day, once every other day, once every third day, or once every day except Sunday. It can help people drink less alcohol or stop drinking altogether. Naltrexone is only part of a complete treatment program that may also include additional forms of counseling and/or monitoring. A combination of naltrexone with buprenorphine (buprenorphine/naltrexone) has been developed, but has not been marketed. Follow your doctor's instructions very closely. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Continue to take naltrexone even if you feel well. This is due to the risk of acute opioid withdrawal if naltrexone is taken, as naltrexone will displace most opioids from their receptors. It is given once per month and has better compliance than the oral formulation. Naltrexone was first made in 1965 and was approved for medical use in the United States in 1984. Naltrexone is an opioid antagonist and works by blocking the effects of opioids, both those from inside and outside the body. A urine test should be done to check for recent opiate drug use. The most common side effects reported with naltrexone are gastrointestinal complaints such as diarrhea and abdominal cramping. During pregnancy, this medication should be used only when clearly needed. Do not use this medicine in larger or smaller amounts or for longer than recommended. Using the same amount you used before could lead to overdose or death. Naltrexone blocks the effects of opioid medication, including pain relief or feelings of well-being that can lead to opioid abuse.

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